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|Synonyms£º||(4-Aminobutyl)guanidinium sulphate; 1-Amino-4-guanidinobutane sulfate salt; 4-Guanidinobutylamine sulfate salt; N-(4-Aminobutyl)guanidine sulfate salt
|Agmatine sulfate (CAS 2482-00-0)
Application: An L-arginine decarboxy analog with neurotransmiter activity
CAS Number: 2482-00-0
Molecular Weight: 228.27
Molecular Formula: C5H14N4.H2SO4
Agmatine sulfate is the sulfate preparation of Agmatine, the decarboxylated form of L-arginine and an endogenous metabolic product highly conserved across life forms.
Agmatine is an intermediate in the biosynthesis of the polyamines putrescine and spermine.
Agmatine binds with high affinity to ¦Á2-adrenergic receptors and imidazoline binding sites and produces blockade of the NMDA-receptor associated cation channels.
The further observations that Agmatine is also stored in synaptic vesicles, is specifically degraded by agmatinase,
and is released from axon terminals by depolarization all suggest that Agmatine has endogenous function as a neurotransmitter.
Agmatine is a competitive inhibitor of NOS (nitric oxide synthase) activity owing to mimicry of the natural NOS substrate arginine.
Appearance: White to off-white powder.
Physical State: Solid
Solubility: Soluble in water (50 mg/ml). Insoluble in ethanol.
Storage: Store at -20¡ã C
Boiling Point: 281.4 ¡ãC at 760 mmHg (Predicted) (tautomer)
Refractive Index: n20D 1.55 (Predicted)
Safety and Reference Information
WGK Germany: 3
PubChem CID: 2794990
Merck Index: 14: 188
MDL Number: MFCD00013109
EC Number: 219-617-3
Beilstein Registry: 3918807
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.